Master (Chinese medicine), Liaoning University of Chinese medicine
Assistant Professor, Department of Basic Chinese medicine, Liaoning University of Chinese medicine
Visiting Researcher, Department of Internal Medicine, School of Medicine, Keio University
Researcher, Department of Internal Medicine, School of Medicine, Keio University
2004-present, Director, Tasly Microcirculation Research Center, Peking University Health Science Center
Acting Chairman,Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences,Peking University
2008-present, Professor,Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences,Peking University
2009-present, Chairman,Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences,Peking University
2009-present Guest Professor,Department of Internal Medicine, School of Medicine,Keio Unviersity
By using the visual and dynamic technologies studies are undertaking in the laboratory to explore the effect of Chinese medicines on the cardiac microcirculatory disturbance and myocardial injury, intending to elucidate the mechanism whereby Chinese medicines exert their actions and further propose the candidates for the new drugs derived form Chinese medicine.
1. Jing-Yan Han*, Yoshinori Horie, Jing-Yu Fan, Kai Sun, Jun Guo, Soichiro Miura and Toshifumi Hibi. Potential of 3.4-dihydroxy-phenyl lactic acid for ameliorating ischemia-reperfusion-induced microvascular disturbance in rat mesentery. Am J Physiol-Gastrointest Liver Physiol. 2009, 296:G36-G44.
2. Qing Yuan, Yu-Ying Liu, Kai Sun, Cun-Hua Chen, Chang-Man Zhou, Chuan-She Wang, An Li, Su-Wen Zhang, Zeng-Liang Ye, Jing-Yu Fan and Jing-Yan Han*. Improving effect of pre-treatment with Yiqifumai on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Shock. 2009, 32(3):310-316.
3. Xiang-Shun Xu, Zhi-Zhong Ma, Fang Wang, Bai-He Hu, Chuan-She Wang, Yu-Ying Liu, Xin-Rong Zhao, Li-Hua An, Xin Chang, Fu-Long Liao, Jing-Yu Fan, Hideyuki Niimi and Jing-Yan Han*. The antioxidant cerebralcare granule？ attenuates cerebral microcirculatory disturbance during ischemia-reperfusion injury. Shock. 2009, 32(2):201-209.
4. Fang Wang, Yu-Ying Liu, Lian-Yi Liu, Chuan-She Wang, Kai Sun, Ji-Ying Yang, Jing-Yu Fan, Jing-Yan Han*. The attenuation effect of 3.4-dihydroxy-phenyl lactic acid and salvianolic acid B on venular thrombosis induced in rat mesentery by photochemical reaction. Clinical Hemorheology and Microcirculation. 2009, 42: 7-18.
5. Chun-Hua Chen, Qin Hu, Jun-Hao Yan, Xiao-Mei Yang, Xian-Zhoug Shi, Ji-Liang Lei, Lin Chen, Hong-Yun Huang, Jing-Yan Han, JoHu-H. Zhang, Chang-Man Zhou. Early inhibition of HIF-1αwith small interfering RNA reduces ischemic-reperfused brain injury in rats. Neurobiology of Disease. 2009, 33:509-517.
6. Qin Hu, Chun-Hua Chen, Jun-Hao Yan, Xiao-Mei Yang, Xian-Zhoug Shi, Jing Zhao, Ji-Liang Lei, Lei Yang, Ke wang, Lin Chen, Hong-Yun Huang, Jing-Yan Han, JoHu-H Zhang, Chang-Man Zhou. Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model. Expermental Neurology. 2009, 316:35-45.
7. Wei-Xing Chen, Fang Wang, Yu-Ying Liu, Qing-Jiang Zeng, Kai Sun, Xin Xue, Xiang Li, Ji-Ying Yang, Li-Hua An, Bai-He Hu, Jin-Hui Yang, Chuan-She Wang, Zhi-Xin Li, Lian-Yi Liu, Jun Zheng, Fu-Long Liao, Dong Han, Jing-Yu Fan and Jing-Yan Han*. The improving effects of Notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion. World J Gastroenterol. 2008, 14(1):49-57.
8. Jun Guo, Kai Sun, Chuan-She Wang, Su-Ping Fang, Yoshinori Horie, Ji-Ying Yang, Yu-Ying Liu, Fang Wang, Lian-Yi Liu, Jing-Yu Fan, Toshifumi Hibi and Jing-Yan Han *. Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on lipopolysaccharide-induced mesenteric microcirculatory disturbance in rats. Shock. 2008, 29 (2):205-211.
9. Jing-Yan Han*, Jing-Yu Fan, Yoshinori Horie, Soichiro Miura, De-Hua Cui, Hiromasa Ishii, Toshifumi Hibi, Hiroshi Tsuneke and Ikuko Kimura. Ameliorating effects of compounds derived from salvia miltiorrhiza root extract on microcirculatiory disturbance and target-organ injury by ishemia-reperfusion. Pharmacology and Therapeutics.2008, 117:280-295.
10. Xian-Wei Wang, Lin Hu, Zhu Zeng, Wei-Juan Yao, Jing-Yan Han, Ying-Yu Zhang, Xiao-Feng Xu, Yu-Ying Liu, Wei-Bo Ka, Da-Gong Sun, Zong-Yao Wen, Shu Chien. Effects of myakuryu on hemorheological characteristics and mesenteric microcirculation of rats fed with a high-fat diet. Biorheology. 2008, 45(5):587-598.
11. Ji-Ying Yang, Kai Sun, Chuan-She Wang, Jun Guo, Xin Xue, Yu-Ying Liu, Jun Zheng, Jing-Yu Fan, Fu-Long Liao, Jing-Yan Han*. Improving effect of post-treatment with panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Clinical Hemorheology and Microcirculation. 2008, 40:119-131.
12. Chun-hua Chen, Qin Hu, Jun-hao Yan, Ji-liang Lei, Li-hua Qin, Xian-zhong Shi, Li-ju Luan, Lei Yang, Ke Wang, Jing-yan Han, Anil Nanda, Chang-man Zhou. Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. Journal of Neurochemistry. 2007, 26: 1831-1841.
13. Kai Sun, Chuan-She Wang, Jun Guo, Yoshinori Horie, Su-Ping Fang, Fang Wang, Yu-Ying Liu, Lian-Yi Liu, Ji-Ying Yang, Jing-Yu Fan and Jing-Yan Han*. Protective effects of ginsenoside Rb1, ginsenoside Rg1 and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery. Life Science. 2007, 81: 509-518.
14. Jing-Yan Han*, Yoshinori Horie, Soichiro Miura, Yasutada Akiba, Jun Guo, Dan Li, Jing-Yu Fan, Yu-Ying Liu, Bai-He Hu, Li-Hua An, Xin Chang, Man Xu, De-An Guo, Kai Sun, Ji-Ying Yang, Su-Ping Fang, Ming-Ji Xian, Masahiro Kizaki, Hiroshi Nagata and Toshifumi Hibi. Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery. World J Gastroenterol. 2007, 13(26):3581-3591.
15. E Iwaoka, T Noguchi, Jing-Yan Han, Xiao-Ping Lin, Ming Gao*. Preventive effect of the Chinse herbal medicine ‘Myakuryu’ on hypertension and stroke in stroke-prone spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology. 2007, 34:51-52.
16. Tomita K.,
Tamiya G,
Ando S,
Ohsumi K,
Chiyo T,
Mizutani A,
Kitamura N,
Toda K,
Kaneko T,
Horie Y,
Han JY, Kato S,
Shimoda M,
Oike Y,
Tomizawa M,
Makino S,
Ohkura T,
Saito H,
Kumagai N,
Nagata H,
Ishii H,
Hibi T. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.
Gut. 2006, 55(3):415-424
17. Fang Wang, Yu-Ying Liu*, Lian-Yi Liu, Jun Guo, Kai Sun, Chuan-She Wang, Jing-Yu Fan and Jing-Yan Han*. Inhibition effect of cardiotonic pills on venous thrombosis induced in rat mesentery by photochemical reaction. Clinical Hemorheology and Microcirculation. 2006, 34:131-138.
18. Masaya Oda, Hiroaki Yokomori, Jing-Yan Han. Regulatory mechanisms of hepatic microcirculatory hemodynamics: hepatic arterial system. Clinical Hemorheolology and Microcirculation. 2006, 34:11-26.
19. Jing-Yan Han*, Yoshinori Horie, Dan Li, Yasutada Akiba, Hiroshi Nagata, Soichiro Miura, Hiromasa Ishii and Toshifumi Hibi. Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion. Clinical Hemorheology and Microcirculation. 2006, 34:103-108
20. Hideyuki Niimi, Suthiluk Patumrajc and Jing-Yan Han. Asian traditional medicine (ATM): recent progress based on scientific on scientific evidences. Clinical Hemorheolology and Microcirculation. 2006, 34: 85-88.
21. Kai Sun, Chuan-She Wang*, Jun Guo, Yu-Ying Liu, Fang Wang, Lian-Yi Liu, Ji-Guo He, Jing-Yu Fan and Jing-Yan Han*. Effect of panax notoginseng saponins on LPS-induced adhesion of leukocyte in rat mesenteric venules. Clinical Hemorheology and Microcirculation. 2006, 34:103-108.
22. Yoshinori Horie, Jing-Yan Han*, Shuka Mori, Masahiro Konishi, Mikio Kajihara, Takehiko Kaneko, Yoshiyuki Yamagishi, Shinzo Kato, Hiromasa Ishii, Toshifumi Hibi. Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically. World J Gastroenterol. 2005, 11(4):511-515.
23. Masaya Oda, Hiroaki Yokomori, Jing-Yan Han. Regulatory mechanisms of hepatic microcirculation. Clinical Hemorheology and Microcirculation. 2003, 29:167-182.
24. Jing-Yan Han,Soichiro Miura, Yasutada Akiba, Hajime Higuchi, Shinzo Kato, Hidekazu Suzuki, Hirokazu Yokoyama, Hiromasa Ishii. Chronic ethanol consumption exacerbates microcirculatory damage in rat mesentery after reperfusion. American Journal of Physiology-gastrointestinal and Liver physiology. 2001, 280:G 939-948
25. Masaya Oda,Jing-Yan Han, Masao Nakamura. Endothelial cell dysfunctin in microvasculature: relevance to disease processes. Clinical Hemorheology and Microcirculation. 2000, 23:199-211.
26. Hajime Higuchi, Iwao Kurose, Dai Fukumura, Jing-Yan Han, Hidetsugu Saito, Soichiro Miura, Ryota Hokari, Naoyuki Watanabe, Shigeyuki Zeki, Masashi Yoshida, Masashi Kitajima, D.Neil Granger, Hiromasa Ishii. Active oxidants mediate IFN-α induced microvascular alterations in rat mesentery. The Journal of Immunology. 1997, 158: 4893-4990.
27. S Miura, D Fukumura, I Kurose, H Higuchi, H Kimura,H H Suzuki, T Shigematsu, J-Y Han,M Tsuchiya, H Ishii. Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine. American Journal of Physiology-gastrointestinal and Liver physiology. 1996, 271:G 461-469.
28. Dai Fukumura, Soichiro Miura, Iwao Kurose, Hajime Higuchi, Hidekazu Suzuki, Hirotoshi Ebinuma, Jing-Yan Han, Naoyuki Watanabe, Go Wakabayashi, Masaki Kitajima, Hiromasa Ishii. IL-1 is an important mediator for microcirculatory changes in endotoxin-induced intestinal mucosal damage. Dig Dig Sci. 1996; 41 (12): 2482-2492.
29. Hidekazu Suzuki, Soichiro Miura, H Imaede, Masaya Suzuki, Jing-Yan Han, Miki Mori, Dai Fukumura, Masaharu Tsuchiya, Hiromasa Ishii. Enhanced levels of chemiluminescence and platelet activating factor increase positive gastric ulcers. Free Red Biol Med. 1996, 20: 449-454.
30. Nobuyuki, Soichiro Miura, Hiroshi Serizawa, Jing-Yan Han, Hiroyuki Kimura, Hiroyuki Imaeda, Hirokazu Tashiro, Masaharu Tsuchiya. In vivo effect of chronic administration of vasoactive intestinalpeptide ongut-associated lymphoid tissues in rats. Regulatory Peptides. 1994, 50: 127-135.
