张炜真 博士 教授
教育经历
Education
1987 广州中山医科大学学士
B.C., Sun Yat-Sen Medical University, China
1990 北京首都医科大学硕士
M. Sc, Capital Medical University, China
1994 北京医科大学博士
Ph. D., Peking Medical University, China
Professional Experience
1994 美国Michigan大学博士后
Postdoctoral fellow, Michigan University, USA
2000 美国Michigan大学研究员
Research Investigator, Michigan University, USA
2004 美国Michigan大学研究助理教授
Research assistant professor, Michigan University, USA
2007 北京大学医学部生理学与病理生理学系教授
Professor，Peking university health science center
研究室成员：
李 茵 副教授
赵 晶 技师
许戈阳 博士生 06级
安文娇 博士生 07级
陈 瑜 八年制博士生 02 级
相新新 硕士生 07 级
丁 力 八年制硕士生 04 级
李自茹 硕士生 08 级
马良肖 八年制硕士生 05 级
研究方向概述：
1、内源性多肽对整体和细胞内营养代谢的调控机制；
2、细胞内能量代谢分子调节基质干细胞分化的分子机制及其在血管损伤修复中的作用。
3、小分子活性物质的心血管损伤和保护作用。
Research Description:
1. Regulation of endogeneous biopeptides on nutrition metabolism
2. Regulation of Metabolic-related molecules on stem cell differentiateon and repairment of cardiovascular damages
3. Effect of small bioactive molecules on cardiovascular functions
Selected Publications (2006-Present):
1. Z Xu G, Li Y, An W, Li S, Guan Y, Wang N, Tang C, Wang X, Zhu Y, Li X, Mulholland MW, Zhang W*. Gastric mTOR signaling regulates ghrelin production and food intake. Endocrinology 2009;150:3637-44.
2. Yin X, Li Y, Xu G, An W, Zhang W*. Ghrelin fluctuation, what determines its production? Acta Biochim Biophys Sin. 2009;41:188-97.
3. Xu G, Li Y, An W, Zhang W*. Ghrelin and cell differentiation. Acta Biochim Biophys Sin. 2008;40:841-7.
4. Zhang W*, Chai B, Li J, Wang H and Mulholland MW. Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology 2008;149:4710-6.
5. Deng F, Ling J, Ma J, Liu C, Zhang W*. Stimulation of intramembranous bone repair by ghrelin. Exp Physiol. 2008;93:872-9.
6. Zhang W*, Michael W. Mulholland. Neuroplasticity in the dorsal vagal complex. In Andres Costa and Eugenio Villalba, ed.: Horizons in Neuroscience Research. Nova Science Publishers, Inc. Hauppauge, NY. 2009.
7. Zhang W* and Michael W. Mulholland. Calcium signaling in enteric glia of the enteric nervous system. In Andres Costa and Eugenio Villalba, ed.: Horizons in Neuroscience Research. Nova Science Publishers, Inc. Hauppauge, NY. 2009.
8. Jiang C, Zhang H, Zhang W, Kong W, Zhu Y, Zhang H, Xu Q, Li Y*, Wang X*. Homocysteine Promotes Vascular Smooth Muscle Cell Migration by Induction of the Adipokine Resistin. AJP-Cell Physiol, 2009 (in press/)
9. Li Y, Jiang C, Xu G, Wang N, Zhu Y, Tang C, Wang X. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes. 2008;57:817-27.
10. Li Y, Jiang C, Wang X, Zhang Y, Shibahara S, Takahashi K. Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues. Peptides. 2007;28:1129-1143.
11. Li Y, Zhang Y, Shibahara S, Takahashi K. Adrenomedullin in adipocyte differentiation of human mesenchymal stem cells. Biochem Biophys Res Commun. 2006;350:616-22.
12. Li Y, Zhang Y, Furuyama K, Yokoyama S, Takeda K, Shibahara S, Takahashi K. Identification of adipocyte differentiation-related regulatory element for adrenomedullin gene repression (ADRE-AR) in 3T3-L1 cells. Peptides. 2006;27:1405-14.
13. Zhang Y, Li Y, Shibahara S, Takahashi K. Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha. Peptides. 2008;29:465-72.
14. Zhang Y, Li Y, Totsune K, Kikuchi K, Murakami O, Shibahara S, Takahashi K. Hypoxia increases endothelin-1 mRNA expression but not immunoreactive endothelin in the medium of T98G glioblastoma cells under cytokine treatment. Peptides. 2006;27:3003-6.
15. Zhang S, Du J, Jin H, Li W, Liang Y, Geng B et al. Endogenous sulfur dioxide aggravates myocardial injury in isolated rat heart with ischemia and reperfusion. Transplantation 2009;87:517-24.
16. Su YW, Liang C, Jin HF, Geng B et al. Hydrogen sulfide regulates cardiac function and structure in adriamycin-induced cardiomyopathy. Circ J 2009;73:741-9.
17. Fang LP, Li H, Tang CS, Geng B, Qi YF, Liu XM. Hydrogen sulfide attenuates the pathogenesis of pulmonary fibrosis induced by bleomycin in rats. Canadian Journal of Physiology and Pharmacology 2009;87:531-538.
18. Lou LX, Geng B*, Chen Y, Yu F, Zhao J, Tang CS. Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats. Clin Exp Pharmacol Physiol 2009;36:612-8.
19. Li XH, Du J, Jin H, Geng B, Wang L, Tang C. Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. Exp Biol Med 2009.
20. Feng X, Chen Y, Zhao J, Tang C, Jiang Z, Geng B*. Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator. Biochem Biophys Res Commun 2009;380:153-9.
21. Fang L, Zhao J, Chen Y, Ma T, Tang C, Liu X, Geng B*. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J Hypertens 2009.
22. Chen YH, Yao WZ, Gao JZ, Geng B, Wang PP, Tang CS. Serum hydrogen sulfide as a novel marker predicting bacterial involvement in patients with community-acquired lower respiratory tract infections. Respirology 2009;14:746-52.
23. Chen YH, Wu R, Geng B, et al. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine 2009;45:117-23.
