研究室PI：杜军保 博士 教授
Junbao Du, M.D, Ph. D.
Phone: 010-83573238
Fax : 010-66128233
E-mail：junbaodu1@126.com
教育经历
Education
1978-1984 北京医科大学医学学士
Medicine, Beijing Medical University, China, B.S.
1984-1989 北京医科大学医学博士
Medicine, Beijing Medical University, China, M.D. Ph.D.
工作经历
Professional Experience
1989-present 北京大学第一医院工作
Peking University First Hospital , Beijing, China
研究室成员：
金红芳 副研究员
齐建光 副教授
张清友 副教授
张春雨 助理研究员
闫 辉 助理研究员
研究室概述：
以众多心肺血管疾病中的重要病理生理环节－肺动脉高压为研究切入点，从具有独特血管生物学特性的小分子气体入手，系统探索了内源性气体信号分子一氧化氮（nitric oxide, NO）及一氧化碳(carbon monoxide, CO) 在肺动脉高压等血管损伤性疾病发病中的生物学意义及其分子机制。开创性地发现一直被认为废气的硫化氢（hydrogen sulfide, H2S）是心血管功能调节的新型内源性气体信号分子，提出H2S 对整个心血管系统的调节作用具有普遍性意义，揭示了气体信号分子的整合调控模式。领导儿童晕厥及其相关功能性心血管疾病、血脂紊乱等多中心临床研究，显著提高了相关疾病的诊治水平。承担及在研国家级及部委级科研项目20余项。发表主要论著360篇，SCI收录75篇。荣获教育部自然科学奖一等奖、高等学校科学技术奖科技进步奖一等奖、高等学校科学技术奖自然科学奖二等奖、北京市科技进步一等奖、二等奖、宋庆龄儿科医学奖等多项学术奖励。
Research Description:
The main interest of the laboratory focuses on the gaseous signal molecules with unique vascular biological functions, targeting on the pathogenesis of pulmonary hypertension which is the key element of various cardiopulmonary diseases. The research group explored systemically the biological significance of endogenous gasotransmitters including nitric oxide, carbon monoxide and hydrogen sulfide in the pathogenesis of vascular injury diseases and their molecular mechanisms. The investigators in the group discover that endogenous hydrogen sulfide is a novel gasotransmitter in the modulation of cardiovascular functions for the first time. Moreover, H2S might play a important role in the regulation of all of cardiovascular physiologic and pathophysiologic events. The novel foundings put forward the research on the regulatory mechanism of gaseous molecules and pathogenesis of cardiopulmonary vascular diseases and obtained the great attention from the scientific peers. In the process of clinical practice, they conducted the multi-center national clinical study on dyslipidemia, the syncope and its related diseases in children and improved the dignostic and treatment level of cardiovascular diseases that often occur in childhood. The principal investigator conducted more than 20 major research projects including National Natural Science Foundation of China (NSFC) for Distinguished Young Scholars, Key project from NSFC, Major Basic Research Project of China, and more than twenty national and provincial research projects. Based on the above outstanding innovative achievements, more than 360 papers were published, 75 of which were published in SCI journals, such as ATVB, J Hypertension, Hypertensive Research, J Pediatrics, BBRC, etc. Moreover, they got The First Prize Award of National Natural Science nominated by Ministry of Education, P.R.China (2005), The First (1999) and the Second (2004) Prize Award of Science and Technology Development of Beijing, P.R.China, Second Prize of Chinese University Natural Sciences Award (2001), First Prize of Scientific and Technological Progress Award of Ministry of Education, China (2007) , Soong Ching Ling Foundation Pediatrics Award (2007) and Third Prize of Chinese Medical Scientific and Technological Award (2005).
Selected Publications (2000-Present):
1. Wang Y, Zhao X, Jin H, Wei H, Li W, Bu D, Tang X, Ren Y, Tang C, Du J. Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol, 2009, 29(2):173-179.
2. Zhao X,Zhang LK,Zhang CY,Zeng XJ,Yan H,Jin HF,Tang CS,DU JB. Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive rats. Hypertens Res,2008;31(8):1619-30.
3. Tianshui Li,Bin Zhao,Cong Wang,Haiying Wang,Zhiwei Liu,Wang Li,Hongfang Jin,Chaoshu Tang,Junbao Du. Regulatory effect of hydrogen sulfide on IL-6,IL-8 and IL-10 levels in the plasma and pulmonary tissue of rats with acute lung injury. Exp Biol Med,2008,233:1081-1087.
4. Suqing Zhang; Junbao Du; Hongfang Jin; Wei Li; Yinfang Liang; Bin Geng; Shukui Li; Chunyu Zhang; Chaoshu Tang. Endogenous sulfur dioxide aggravates myocardial injury in isolated rat heart with ischemia and reperfusion. Transplantation. 2009, 87(4):517-524.
5. B Zhang,C Tang,Z Jiang,Y Qi,Y Pang,J Du. Effect of adrenomedullin on vascular calcification in rats. Z Kardiol 2002,91:568-574.
6. Wei Bing, Du Junbao, Qi Jianguang, Li Jian,Tang Chaoshu. L-Arginine impacts pulmonary vascular structure in rats with an aortocaval shunt. J Surg Res,2002,108:20-31.
7. Shi Yun, Du Junbao,Gonglimin, Zeng Chaomei,Tangxiuying,Tang Chaoshu. The regulating effect of heme oxygenase/carbon monoxide on hypoxic pulmonary vascular structural remodeling. Biochem Biophys Res Commun,2003,306:523-529.
8. Zhang Chunyu, Du Junbao, Bu Dingfang,Yan Hui,Tang Xiuying,Tang Chaoshu. The regularory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats. Biochem Biophys Res Commun,2003,302:810-816.
9. Yan Hui, Junbao Du, Chaoshu Tang, Geng Bin, Hongfeng Jiang. Changes in arterial hydrogen sulfide (H2S) content during septic shock and endptoxin shock in rats. J Infection,2003,47:155-160.
10. Zhang B,Tang C, Du J. Changes of heme-oxygonase carbon monoxide system in vascular calcification in rats. Life Sci,2003,72(9):1027-1037.
11. Guangzhen Zhong, Fengrong Chen, Youqin Cheng,Chaoshu Tang, Junbao Du. The role of hydrogen sulfide in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J Hypertension,2003,21:1879-1885.
12. Limin Gong, Junbao Du, Lin Shi, Yun Shi, Chao-shu Tang. Effects of endogenous carbon monoxide on collagen synthesis in pulmonary artery in rats under hypoxia. Life Sci,2004,74:1225-1241.
13. Junbao Du, Yan Hui, Yiufai Cheung, Geng Bin, Hongfang Jiang, Xiaobo Chen,Chaoshu Tang. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels,2004,19:75-80.
14. Z Qingyou, D Junbao, C Jianjun, L Wanzhen. Association of clinical characteristics of unexplained syncope with the outcome of head-up tilt tests in children. Pediatr Cardiol,2004,25(4):360-364.
15. B Zhang, S Wang, Y Pang, C Tang, J Du. Alteration of heme-oxygenase-carbon monoxide pathway in calcified vascular smooth muscle cells. Z Kardiol,2004,93:109-115.
16. Zhang Qingyou, Du Junbao, Zhou Weijin, Yan Hui, Tang Chaoshu, Zhang Chunyu. Impact of hydrogen sulfide on carbon monoxide oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension. Biochem Biophys Res Commun,2004,317:30-37.
17. Hui Yan, Junbao Du, Chaoshu Tang. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun,2004,313:22-27.
18. Du Junbao, Yan Hui, Wei Bing, Qi Jianguang, Tang Chaoshu. Effect of L-arginine on collagen of high flow-induced pulmonary arterial remodeling. Circ J, 2005,69:603-608.
19. Li Xiaohui, Du Junbao, Shi Lin, Li Jian, Tang Xiuying, Qi Jianguang, Wei Bing, Jin Hongfang, Tang Chaoshu. Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats. Circ J. 2005;69(11):1418-1424.
20. Jin Hongfang, Cong Bailin, Zhao Bin, Zhang Chunyu, Liu Xinmin, Zhou Weijuin, Shi Ying, Tang Chaoshu, Du Junbao. Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling. Life Sci,2006,78:1299-1309.
21. Wang Yanfei, Shi Lin, Du Junbao, Tang Chaoshu. Impact of L-arginine on hydrogen sulfide/cystathionine-γ-lyase pathway in rats with high blood flow-induced pulmonary hypertension,Biochem Biophys Res Commun 2006,345:851-857.
22. Kan Puikuan,Zhang Chunyu,Fan Jin,Tang Chaoshu,Du Junbao. Inhalation of nebulized nitroglycerin,a nitric oxide donor,for the treatment of pulmonary hypertension induced by high pulmonary blood flow. Heart Vessels. 2006,21(3): 169-179.
23. Zhang Qingyou,Du Junbao,Tang Chaoshu. The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope. J Pediatr 2006;149:777-80.
24. Xiaohui Li,Junbao Du,Hongfang Jin,Xiuying Tang,Dingfang Bu,Chaoshu Tang. The regulatory effect of endogenous hydrogen sulfide on pulmonary vascular structure and gasotransmitters in rats with pulmonary blood flow. Life Sci,2007,841-849.
25. Zhang Q,Jin H,Wang L,Chen J,Tang C,Du J.Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents. Med Sci Monit. 2008;14(4):CR199-203.
26. Liao Y, Liu Y, Mi J, Tang C, Du J. Risk factors for dyslipidemia in Chinese children. Acta Paediatr. 2008 ,97(10): 1449-1453.
27. Su YW, Liang C, Jin HF, Tang XY, Han W, Chai LJ, Zhang CY, Geng B, Tang CS, Du JB.Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy. Circ J. 2009, 73(4):741-749.
28. Du Junbao, Li Shuzheng, Wang Baolin, Li Yuan. Doppler echocardiographic evaluation of pulmonary artery pressure in pneumonia of infants and children. Pediatr Pulmonol,1991,10:296-298.
29. Du Junbao,Jia Jianfeng,Li Wanzhen,Zhao Bin,Zeng Heping. Nitric Oxide impacts Endothelin-1 Gene expression in Intrapulmonary arteries of Chronically Hypoxic Rats. Angiology,1999,50(6):479-485.
30. Li XH, Jin HF, Bin G, Wang L, Tang CS, Du J. Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow.Exp Biol Med (Maywood). 2009, 234(5):504-512.
